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天然化合物

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カタログ番号	製品名	別名	ターゲット
T1767	BMH-21	BMH21	DNA/RNA Synthesis
	BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.		DNA/RNA Synthesis
T3489	Dasabuvir	ABT-333	HCV Protease
	Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra...		HCV Protease
T4686	Simeprevir	TMC435,TMC-435350,Olysio	HCV Protease , SARS-CoV
	Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.		HCV Protease , SARS-CoV
T6446	Clevudine	L-FMAU,Levovir	HBV , DNA/RNA Synthesis
	Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The ...		HBV , DNA/RNA Synthesis
T0220	Foscarnet sodium	Phosphonoformate	Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis
	Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
T6729	Lomibuvir	VX-222,VCH-222	HCV Protease
	Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir...		HCV Protease
T8972	FIT-039		Others , DNA/RNA Synthesis , CDK , HSV
	FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a pr...		Others , DNA/RNA Synthesis , CDK , HSV
T10104	3,4-Dihydroxybenzylamine hydrobromide	NSC 263475 hydrobromide	Others , DNA/RNA Synthesis
	3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activit...		Others , DNA/RNA Synthesis
T8841	IMT1	Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)	Others , DNA/RNA Synthesis , Mitochondrial Metabolism
	IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.		Others , DNA/RNA Synthesis , Mitochondrial Metabolism
T0964	Floxuridine	5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640	Apoptosis , Nucleoside Antimetabolite/Analog , Others , DNA/RNA Synthesis , Antibacterial , HSV
	Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
T8842	IMT1B	3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974	Others , DNA/RNA Synthesis
	IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of the mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression. This action confers it...		Others , DNA/RNA Synthesis
T10493	Beclabuvir	BMS-791325	Others
	Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase. It inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 (IC50 < 28 nM).		Others
T9051	ZYN57939	MTR-106	DNA/RNA Synthesis
	ZYN57939 (MTR-106) is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases. ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines.		DNA/RNA Synthesis
T27696	JTK-109	JTK109	HCV Protease
	JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.		HCV Protease
T6833	Favipiravir	T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide	Others , SARS-CoV , Influenza Virus , DNA/RNA Synthesis
	Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.		Others , SARS-CoV , Influenza Virus , DNA/RNA Synthesis
T16710	Mericitabine	R-7128,RG 7128,PSI 6130 diisobutyrate	HCV Protease
	Mericitabine (R-7128) is a nucleoside HCV NS5B polymerase inhibitor. It acts as an RNA chain terminator and prevents the elongation of RNA transcripts during replication.		HCV Protease
T15282	Filibuvir	PF-00868554	HCV Protease , DNA/RNA Synthesis
	Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM.		HCV Protease , DNA/RNA Synthesis
T69941	CMX-521
	CMX521 is an antiviral drug candidate, which was developed for the treatment of norovirus, though it also shows efficacy against related viral diarrheas such as rotovirus and some sapoviruses, astroviruses and adenovirus...
T9617	RdRP-IN-2		SARS-CoV
	RdRP-IN-2 is a RNA dependent RNA polymerase (RdRp) inhibitor. It significantly inhibits SARS-CoV-2 RdRp with an IC50 of 41.2 µM.It also inhibits Feline coronavirus (FIPV) replication.		SARS-CoV
T2117	PSI-6206	2'-deoxy-2'-fluoro-2'-C-methyluridine,RO 2433,GS-331007	HCV Protease
	PSI-6206 (RO 2433) (RO2433) is a selective HCV RNA polymerase inhibitor.		HCV Protease
T63253	AVG-233		DNA/RNA Synthesis , RSV
	AVG-233 is an orally available RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity that blocks respiratory syncytial virus and SARS-CoV-2 replication.AVG-233 is used in the study of respiratory syncytia...		DNA/RNA Synthesis , RSV
T70388	(S)-Enitociclib	VIP152	CDK
	(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that induces complete regression of MYC+ lymphomas by inhibiting RNA polymerase II-mediated transcription of anti-apoptotic and pro-survival proteins.		CDK
T8886	NITD-2		DNA/RNA Synthesis
	NITD-2 is a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly. Dengue virus (DENV) is the most prevalent mosquito- borne viral pathogen in hu...		DNA/RNA Synthesis
T28918	Talviraline	Bay 10-8979,HBY 097,Bay10-8979,Bay-108979,Bay108979,Bay 108979,Bay-10-8979	HIV Protease , DNA/RNA Synthesis
	Talviraline (Bay 10-8979) is an RNA-induced DNA polymerase inhibitor.Talviraline is a potent inhibitor of HIV-1-induced cell killing and HIV-1 replication in a variety of human cell lines, as well as in fresh human perip...		HIV Protease , DNA/RNA Synthesis
T78226	Methyl 2-amino-5-bromobenzoate	Methyl 5-Bromoanthranilate	HCV Protease , Antifungal
	Methyl 2-amino-5-bromobenzoate (Methyl 5-Bromoanthranilate) is a hepatitis C virus NS5b RNA polymerase inhibitor with antimicrobial activity that inhibits Pseudomonas aeruginosa infections and is involved in the producti...		HCV Protease , Antifungal
T12006	Metarrestin	ML246	DNA/RNA Synthesis
	Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (...		DNA/RNA Synthesis
T28762	Setrobuvir	RO-5466731,ANA-598,RG7790,ANA598,RG-7790	HCV Protease , SARS-CoV , DNA/RNA Synthesis
	Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding aff...		HCV Protease , SARS-CoV , DNA/RNA Synthesis
T14495	Baloxavir	Baloxavir acid,S-033447	Influenza Virus
	Baloxavir (S-033447) is a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.		Influenza Virus
T11068	DNA31		Others
	DNA31 is a potent RNA polymerase inhibitor.		Others
T27616	BMS-986094	INX 08189,INX-189,INX189,INX08189,INX-08189
	INX 08189 is an RNA-directed RNA polymerase (NS5B) inhibitor.
T25590	L-742001 Hydrochloride	L-742001,L742001 Hydrochloride,L 742001,L742001
	L-742001 Hydrochloride is an RNA polymerase inhibitor.
T27204	DPC-963	DMP 963,DMP963,DMP-963,DPC 963,DPC963
	DPC-963 is a RNA-directed DNA polymerase inhibitor.
T24514	Myxopyronin A	Myx,Myxopyronin-A
	Myxopyronin A is an inhibitor of bacterial RNA polymerase.
T16945	Streptolydigin	Portamycin	Antibacterial
	Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor (Ki...		Antibacterial
T27530	HCV-086	HCV086
	HCV-086, a RNA-directed RNA polymerase (NS5B) inhibitor, is used for the treatment of HCV infection.
T27485	GSK-625433
	GSK-625433, a homochiral inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, has the ability to inhibit the polymerase of both HCV genotypes 1a and 1b.
T40359	Thio-ITP	6-Thio-ITP,Thio-ITP,6-Mercaptopurine-riboside-5'-triphosphate,6-Thioinosine 5′-triphosphate
	Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I...
T28984	TMC-649128	TMC 649128
	TMC-649128, a RNA polymerase NS5B inhibitor, is used for the treatment of HCV infection.
T10491L	Galidesivir hydrochloride	BCX 4430 hydrochloride,Immucillin-A hydrochloride	Others
	Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.		Others
T28492	R-18893	R18893
	R-18893, a RNA-directed DNA polymerase inhibitor, is used potentially for the treatment of HIV-1 infection.
T19688	Lodenosine	FddA,3'-dideoxyarabinosyladenine,Fddl,2'-F-dd-ara-A,2'-Fluoro-2',DDG-1
	Lodenosine is an inhibitor of RNA-directed DNA polymerase, and potentially for the treatment of HIV.
T71748	RK-0404678
	RK-0404678 is a novel inhibitor of dengue virus NS5 RNA-dependent RNA polymerase (RdRp), inhibiting the DENV type 2 (DENV2) RdRp activities.
T26963	CBR-2092	TNP2092,CBR2092,TNP-2092,TNP 2092
	CBR-2092 is a DNA-directed RNA polymerase and DNA topoisomerase inhibitor. CBR-2092 exhibited rifampin-like potency as an inhibitor of RNA polymerase, was an equipotent (balanced) inhibitor of DNA gyrase and DNA topoisom...
T23803	BMH-23	BMH23,BMH 23
	BMH-23 is an RNA polymerase I inhibitor that acts by causing nucleolar stress and showing potent anticancer activity across many tumor types.
T23802	BMH-22	BMH22
	BMH-22 is an RNA polymerase I inhibitor that acts by causing nucleolar stress and showing potent anticancer activity across many tumor types.
T23804	BMH-9	BMH 9
	BMH-9 is an RNA polymerase I inhibitor that acts by causing nucleolar stress and showing potent anticancer activity across many tumor types.
T63593	Dasabuvir sodium
	Dasabuvir (ABT-333) sodium is a non-nucleoside hepatitis C virus (HCV) polymerase inhibitor. sodium exhibits inhibition of the RNA-dependent RNA polymerase (RNA polymerase) encoded by the HCV NS5B gene. sodium inhibits D...
T70855	Favipiravir sodium
	Favipiravir sodium is a selective inhibitor of viral RNA-dependent RNA polymerase with activity against many RNA viruses, influenza viruses, West Nile virus, yellow fever virus, foot-and-mouth disease virus as well as o...
T74631	RNA polymerase II-IN-2
	RNA polymerase II-IN-2 (compound 20iii), a potent inhibitor of RNA polymerase II (Pol II) with a K i value of 9.5 nM, demonstrates cytotoxicity against cancer cells, exhibiting toxicity levels 2 and 5 times higher than α...
T73323	RdRP-IN-5		Influenza Virus
	RdRP-IN-5 (compound 20), a potent inhibitor of the influenza virus RNA-dependent RNA polymerase (RdRP), has potential application in influenza research [1].		Influenza Virus

Compounds

BMH-21

T1767

Synonym: BMH21

Target: DNA/RNA Synthesis

Synonym: TMC435,TMC-435350,Olysio

Target: HCV Protease, SARS-CoV

Clevudine

T6446

Synonym: L-FMAU,Levovir

Target: HBV, DNA/RNA Synthesis

Foscarnet sodium

T0220

Synonym: Phosphonoformate

Target: Virus Protease, Reverse Transcriptase, DNA/RNA Synthesis

Lomibuvir

T6729

Synonym: VX-222,VCH-222

Target: Others, DNA/RNA Synthesis, CDK, HSV

3,4-Dihydroxybenzylamine hydrobromide

T10104

Synonym: NSC 263475 hydrobromide

Target: Others, DNA/RNA Synthesis

IMT1

T8841

Synonym: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)

Target: Others, DNA/RNA Synthesis, Mitochondrial Metabolism

Floxuridine

T0964

Synonym: 5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Others, DNA/RNA Synthesis, Antibacterial, HSV

IMT1B

T8842

Synonym: 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974

Target: Others, DNA/RNA Synthesis

Target: DNA/RNA Synthesis

Synonym: T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide

Target: Others, SARS-CoV, Influenza Virus, DNA/RNA Synthesis

Mericitabine

T16710

Synonym: R-7128,RG 7128,PSI 6130 diisobutyrate

Target: HCV Protease, DNA/RNA Synthesis

Synonym: 2'-deoxy-2'-fluoro-2'-C-methyluridine,RO 2433,GS-331007

Target: DNA/RNA Synthesis, RSV

Target: DNA/RNA Synthesis

Talviraline

T28918

Synonym: Bay 10-8979,HBY 097,Bay10-8979,Bay-108979,Bay108979,Bay 108979,Bay-10-8979

Target: HIV Protease, DNA/RNA Synthesis

Methyl 2-amino-5-bromobenzoate

T78226

Synonym: Methyl 5-Bromoanthranilate

Target: HCV Protease, Antifungal

Metarrestin

T12006

Synonym: ML246

Target: DNA/RNA Synthesis

Setrobuvir

T28762

Synonym: RO-5466731,ANA-598,RG7790,ANA598,RG-7790

Target: HCV Protease, SARS-CoV, DNA/RNA Synthesis

Baloxavir

T14495

Synonym: Baloxavir acid,S-033447

Target: Influenza Virus

Synonym: INX 08189,INX-189,INX189,INX08189,INX-08189

Target:

L-742001 Hydrochloride

T25590

Synonym: L-742001,L742001 Hydrochloride,L 742001,L742001

Target:

DPC-963

T27204

Synonym: DMP 963,DMP963,DMP-963,DPC 963,DPC963

Target:

Myxopyronin A

T24514

Synonym: Myx,Myxopyronin-A

Target: Antibacterial

Synonym: 6-Thio-ITP,Thio-ITP,6-Mercaptopurine-riboside-5'-triphosphate,6-Thioinosine 5′-triphosphate

Galidesivir hydrochloride

T10491L

Synonym: BCX 4430 hydrochloride,Immucillin-A hydrochloride

Synonym: FddA,3'-dideoxyarabinosyladenine,Fddl,2'-F-dd-ara-A,2'-Fluoro-2',DDG-1

Synonym: TNP2092,CBR2092,TNP-2092,TNP 2092

Target:

BMH-23

T23803

Synonym: BMH23,BMH 23

RNA polymerase II-IN-2

Target: Influenza Virus

カタログ番号	製品名	別名	ターゲット
T6S0139	Neobavaisoflavone		Apoptosis , DNA/RNA Synthesis
	1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si...		Apoptosis , DNA/RNA Synthesis
T6194	Fidaxomicin	Tiacumicin B,OPT-80,Clostomicin B1,PAR-101	Apoptosis , DNA/RNA Synthesis , Antibacterial , Antibiotic
	Fidaxomicin (Tiacumicin B) is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults. Fidaxomicin has minimal systemic absorption and has not been linked to serum enzyme el...
T3376	Cynaroside	Luteoloside,Luteolin 7-β-D-Glucopyranoside,Luteolin 7-O-Glucoside,Luteolin 7-O-β-D-glucoside,Luteolin 7-glucoside	Others , Influenza Virus , DNA/RNA Synthesis
	Cynaroside (Luteolin 7-O-Glucoside) is a flavone, a flavonoid-like chemical compound. It has an anti-oxidant effect, inhibiting lipid and protein oxidation.		Others , Influenza Virus , DNA/RNA Synthesis
T8347	Rifamycin S		Reactive Oxygen Species , ROS , Antibacterial , Antibiotic
	Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria		Reactive Oxygen Species , ROS , Antibacterial , Antibiotic
TN2222	Sotetsuflavone		Others
	Sotetsuflavone, with an IC50 of 0.16 μM, stands as the most active compound in its series, acting as a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase).		Others
T16673	Pseudouridimycin	PUM	Others
	Pseudouridimycin is a C-nucleoside analogue. Pseudouridimycin is an antibiotic and is a selective bacterial RNA polymerase (RNAP) inhibitor. It is effective against both Gram-negative and Gram-positive bacteria.		Others
T36667	2'-Deoxyadenosine-5'-triphosphate	dATP,Deoxyadenosine 5-triphosphate	DNA/RNA Synthesis , Endogenous Metabolite
	2'-Deoxyadenosine-5'-triphosphate (Deoxyadenosine 5-triphosphate) (dATP) is a naturally occurring small molecule nucleotide used in cells for DNA synthesis or replication. 2'-Deoxyadenosine-5'-triphosphate (dATP) is a su...		DNA/RNA Synthesis , Endogenous Metabolite

天然物製品

Neobavaisoflavone

T6S0139

Synonym:

Target: Apoptosis, DNA/RNA Synthesis

Fidaxomicin

T6194

Synonym: Tiacumicin B,OPT-80,Clostomicin B1,PAR-101

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic

Cynaroside

T3376

Synonym: Luteoloside,Luteolin 7-β-D-Glucopyranoside,Luteolin 7-O-Glucoside,Luteolin 7-O-β-D-glucoside,Luteolin 7-glucoside

Target: Others, Influenza Virus, DNA/RNA Synthesis

Rifamycin S

T8347

Synonym:

Target: Reactive Oxygen Species, ROS, Antibacterial, Antibiotic

2'-Deoxyadenosine-5'-triphosphate

T36667

Synonym: dATP,Deoxyadenosine 5-triphosphate

Target: DNA/RNA Synthesis, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-02396	Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) Z Protein (His)	LASV	E. coli
	Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruit...

Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) Z Protein (His)

TMPH-02396

Species: LASV

Expression System: E. coli